To develop preclinical models reproducing accurately the different clinical types of leukemia and lymphoma as well as allogeneic transplantation, based on transformed cell lines, patient’s samples and murine models
To develop in vivo and in vitro assays for the analysis of novel targeted
To analyze microenvironment regulatory networks
To study molecular mechanisms of drug resistance.
To analyze the implications of molecular lesions in the leukemogenesis and chemorresistance through genomic edition using CRISPR-CAS9 technology and minigenes, among others.
To generate mutant mice to study the impact of alterations on leukemogenesis